Premium
Phospholipid composition of liver in rats fed high levels of 13‐ cis retinoic acid
Author(s) -
Alam Bassima S.,
Alam Syed Q.
Publication year - 1983
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02536109
Subject(s) - retinoic acid , phospholipid , phosphatidylcholine , phosphatidylethanolamine , lipidology , clinical chemistry , composition (language) , biochemistry , medicine , fatty acid , endocrinology , chemistry , biology , linguistics , philosophy , membrane , gene
The composition of liver phospholipids was studied in rats fed for 4 weeks diets containing 0, 100 or 300 mg 13‐ cis retinoic acid per kg diet. There was a significant decrease in phosphatidylcholine content, whereas the levels of phosphatidylethanolamine were slightly increased in liver phospholipids of rats fed 13‐ cis retinoic acid. The fatty acid composition of total phospholipids, PC, PE, and PI+PS fractions revealed a general increase in the levels of 18∶2 and 20∶3ω6, whereas the levels of 20∶4ω6 and C 22 fatty acids were reduced in most of the hepatic phospholipids isolated from rats fed 13‐ cis retinoic acid containing diets. A decrease in the double‐bond index of fatty acids was also observed in phospholipids of rats fed 13‐ cis retinoic acid. The data suggest that high levels of 13‐ cis retinoic acid may possibly be influencing the activities of microsomal desaturating and chain‐elongating enzymes in the liver.