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Effect of dietary α‐linolenate/linoleate balance on endotoxin‐induced hepatitis in mice
Author(s) -
Watanabe Shiro,
Okuyama Harumi
Publication year - 1991
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02536074
Subject(s) - lipidology , clinical chemistry , linolenate , balance (ability) , chemistry , food science , biochemistry , medicine , fatty acid , physical therapy
Mice were fed diets with three different ratios of α‐linolenate (18∶−3) to linoleate (18∶2n−6), and the severity of hepatitis during endotoxic shock was compared. Dietary enrichment with α‐linolenate increased the severity of hepatitis and the mortality induced by lipopolysaccharide (LPS) in combination with D‐galactosamine (GalN). Differences in the dietary α‐linolenate/linoleate balance were mainly reflected in the levels of arachidonate and eicosapenatenoate in liver phospholipids. Pretreatement of mice with indomethacin was found to also enhance the severity of GalN/LPS‐hepatitis. This indicated that cyclooxygenase products of arachidonate may suppress the development of GalN/LPS‐hepatitis. The enhancement by high α‐linolenate diets was not observed when a lethal dose of LPS in the absence of GalN was given. Our results indicate that there are pathophysiological conditions of endotoxin‐induced hepatitis under which cyclooxygenase products of arachidonate play protective roles.