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Induction of geranyl pyrophosphate pyrophosphatase activity by cholesterol‐suppressive isoprenoids
Author(s) -
Case Gary L.,
He Lei,
Mo Huanbiao,
Elson Charles E.
Publication year - 1995
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02536045
Subject(s) - terpenoid , chemistry , pyrophosphatase , pyrophosphatases , lipidology , pyrophosphate , farnesol , clinical chemistry , cholesterol , biochemistry , stereochemistry , enzyme
Diets supplemented (1 mmol/kg) with thymol, carvacrol, and β‐ionone significantly decreased the serum cholesterol levels of cockerels. These mevalonate‐derived end products of plant secondary metabolism (isoprenoids) had no impact on two cytosolic prenyl alcohol (and ethanol) dehydrogenase activities; each treatment increased microsomal geranyl pyrophosphate pyrophosphatase activity by greater than twofold. The structural diversity of the isoprenoids which suppress cholesterol synthesis may be reconciled by their ability to increase pyrophosphatase activity, thus leading to the production of the endogenous, post‐transcriptional regulator of 3‐hydroxy‐3‐methyglutaryl coenzyme A reductase activity.