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Metabolic transformation of intracraneally injected [1‐ 14 C]linoleic and [1‐ 14 C]α‐linolenic acids in malnourished developing rats
Author(s) -
De Tomas Maria Elena,
Mercuri Osvaldo,
Serres Cristina
Publication year - 1991
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535973
Subject(s) - polyunsaturated fatty acid , lipidology , clinical chemistry , linoleic acid , chemistry , phosphatidylethanolamine , phosphatidylcholine , biochemistry , lactation , metabolism , fatty acid , arachidonic acid , medicine , endocrinology , biology , phospholipid , pregnancy , enzyme , membrane , genetics
The effect of a low protein diet during pregnancy and lactation on the fatty acid composition of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) from brains of ten‐day‐old rats was studied. The results indicated that partial deprivation of protein during early development was associated with an increase in the fatty acids of the n−9 family in PC. The fatty acids of the linoleic acid series decreased in PE but were not modified in PC. These minor changes did not affect the double bond index values either in PC or in PE. The effect of protein depletion on the in vivo metabolic transformation of intracraneally injected [1‐ 14 C]linoleic and [1‐ 14 C]α‐linolenic acids was also studied. The percentage distribution of the labeled precursors and their derivatives among PC and PE differed from that of mass distribution. These results indicate that the direct uptake of polyunsaturated fatty acids from the blood and/or the low turnover rate of these acids incorporated into PC and PE might be involved in maintaining the fatty acid pattern of these brain lipids.