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The effect of bleomycin on the uptake and incorporation of [ 14 C] choline into phospholipids in hamster lung tissue slices
Author(s) -
Hollinger Mannfred A.,
Giri Shri N.
Publication year - 1990
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535911
Subject(s) - bleomycin , phospholipid , phospholipidosis , hamster , pharmacology , in vitro , xenobiotic , choline , lipidology , lung , chemistry , cytidine , biochemistry , drug , clinical chemistry , biology , medicine , endocrinology , chemotherapy , membrane , enzyme
Intratracheal administration of the anticancer drug bleomycin to hamsters produced an increase in the uptake and incorporation of [ 14 C] choline into phospholipids of lung slices in vitro . The stimulatory effect is opposite to the results obtained previously using [ 14 C] acetate and would appear to occur distal to cytidine diphosphocholine. Although alternate explanations are possible, the results are consistent with morphological evidence, published by others, indicating an increase in lung phospholipid following bleomycin treatment, and illustrate the significance of precursor selection when evaluating the effects of xenobiotics on phospholipid synthesis.