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The interaction of prostaglandin E 1 with serum lipoproteins possible role in cholesterol homeostasis
Author(s) -
Bergelson Lev D.
Publication year - 1990
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535895
Subject(s) - chemistry , clinical chemistry , phosphatidylcholine , lipidology , lecithin , prostaglandin , cholesterol , medicine , sterol o acyltransferase , endocrinology , lipoprotein , prostaglandin e , substrate (aquarium) , cholesterylester transfer protein , biochemistry , biology , phospholipid , membrane , ecology
Prostaglandin (PG) E 1 significantly stimulates the rate of cholesterol esterification in plasma. This effect could be attributed to an enhancement by PGE 1 of the interlipoprotein transfer of phosphatidylcholine and cholesteryl esters, i.e. , the substrate and product of lecithin‐cholesterol acyltransferase (LCAT). The enhancement effect appears to be due to a rearrangement of the lipoprotein surface induced by specific interaction of PGE 1 with some apolipoproteins, although the binding capacity of serum lipoproteins for PGE 1 was found to be rather weak. To explain these findings, an hypothetical non‐equilibrium model was put forward. The purpose of the present article is to summarize available data on the PGE 1 ‐lipoprotein interaction.