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Effect of phosphatidylcholine on the α‐lactalbumin‐induced fusion of vesicles
Author(s) -
Park Byoung Sun,
Kim Jeongha,
Kim Uh Hee,
Kim Hyoungman
Publication year - 1989
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535759
Subject(s) - vesicle , phosphatidylcholine , chemistry , lipidology , lactalbumin , fusion , lipid vesicle , chromatography , clinical chemistry , biophysics , biochemistry , phospholipid , biology , philosophy , membrane , linguistics
Previous studies on α‐lactalbumin induced fusion of phosphatidylserine/phosphatidylethanolamine vesicles are extended to vesicles composed of various combinations of phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine and cardiolipin. It was found that inclusion of phosphatidylcholine in the vesicles results in a depression of fusion. This depression of fusion appears to be caused by a reduction in the amount of irreversibly bound α‐lactalbumin to vesicles containing phosphatidylcholine. It is suggested that in this system fusion is dependent upon the extent by which a particular protein segment penetrates the bilayer.