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Effect of aging and dietary restriction on bile acid metabolism in rats
Author(s) -
Ferland G.,
Tuchweber B.,
Perea A.,
Yousef I. M.
Publication year - 1989
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535757
Subject(s) - bile acid , phospholipid , ursodeoxycholic acid , medicine , chenodeoxycholic acid , cholic acid , endocrinology , deoxycholic acid , clinical chemistry , secretion , metabolism , chemistry , biology , biochemistry , membrane
The aim of the present study was to determine whether increased output of phospholipid in bile during aging may be due to alteration of bile acid composition and stimulated hydrophobic bile acid formation. In female Sprague‐Dawley rats we examined the influence of aging and life long dietary restriction (60% of the ad libitum intake) on bile flow, total bile acid secretion, bile acid composition and conjugation pattern, as well as phospholipid output. Rats were cannulated at 3.5, 8–12 and 24–27 months of age and bile collected for analysis. With age, there was a significant reduction in bile flow and total bile acid secretion, however, phospholipid output increased. Restriction of dietary intake exerted a beneficial effect on the age‐related decline in bile formation. Studies of bile composition indicated that 12α‐hydroxylated bile acids (cholic acid and deoxycholic acid) secretion decreased in aged rats compared to 3.5‐month‐old rats. This was associated with a corresponding increase in secretion of chenodeoxycholic acid and hyodeoxycholic‐ursodeoxycholic acid. However, the magnitude of the change in secretion of these bile acids could not account for the increased output of phospholipid in bile.