Stimulation of fatty acid synthesis by 4β‐phorbol‐12‐myristate‐13‐acetate in isolated rat hepatocytes | Zendy

Nomura Takahide | Zendy; Tachibana Masakatsu | Zendy; Nomura Hiroko | Zendy; Hagino Yasumichi | Zendy

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Stimulation of fatty acid synthesis by 4β‐phorbol‐12‐myristate‐13‐acetate in isolated rat hepatocytes

Author(s) -

Nomura Takahide,

Tachibana Masakatsu,

Nomura Hiroko,

Hagino Yasumichi

Publication year - 1986

Publication title -

lipids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 120

eISSN - 1558-9307

pISSN - 0024-4201

DOI - 10.1007/bf02535703

Subject(s) - clinical chemistry , phorbol , stimulation , protein kinase c , fatty acid synthesis , lipidology , fatty acid , extracellular , phorbol ester , chemistry , biochemistry , medicine , endocrinology , biology , kinase

The tumor‐promoting agent 4β‐phorbol‐12‐myristate‐13‐acetate (TPA) is shown to be a potent stimulator of fatty acid synthesis in isolated rat hepatocytes. The maximal effect of TPA is seen at 10 −6 M, and the concentration for half‐maximal effect is ca. 10 −8 M. Stimulation of fatty acid synthesis by TPA is shown not to require the presence of extracellular Ca ++ . TPA produces a significant increase in lactate and pyruvate accumulation. The possible involvement of protein kinase C in short‐term regulation of fatty acid synthesis in the liver is discussed.

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