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Distal small bowel resection does not modify the intestinal 3‐hydroxy‐3‐methylglutaryl CoA reductase activity
Author(s) -
Molina M. T.,
Vazquez C. M.
Publication year - 1988
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535677
Subject(s) - reductase , coenzyme a , hmg coa reductase , small intestine , hydroxymethylglutaryl coa reductase , lipidology , medicine , clinical chemistry , intestinal mucosa , endocrinology , resection , large intestine , gastroenterology , biology , chemistry , enzyme , biochemistry , surgery
The activity of 3‐hydroxy‐3‐methylglutaryl coenzyme‐A reductase (HMG‐CoA red.) has been evaluated in rat jejunal, caecal and colonic mucosa adapting to 50% or 75% distal small bowel resection (SBR). Six wk after surgery, the total activity and the activity state (active form) of the enzyme were determined. The results show that HMG‐CoA red. activity was stimulated per organ but not per unit mass in the mucosa adapting to SBR. As a side result, we noted regional differences in the active/total reductase ratio (RA/RT) for HMG‐CoA red. that was lower in small intestine compared with that of the large intestine.