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Investigations of the origin of the furan fatty acids (F‐acids)
Author(s) -
GorstAllman Charles P.,
Puchta Volker,
Spiteller G.
Publication year - 1988
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535648
Subject(s) - furan , lipidology , chemistry , linoleic acid , chromatography , mass spectrometry , gas chromatography , tetrahydrofuran , organic chemistry , clinical chemistry , urine , fatty acid , biochemistry , solvent
The possible role of linoleic acid as a biogenetic precursor of the furan fatty acids (F‐acids) was investigated in in vivo experiments in the rat, using a C 19 analogue of linoleic acid and gas chromatography‐mass spectrometry. No evidence of incorporation of this compound into the F‐acids was found. Using an improved analysis procedure by converting F‐acids into their tetrahydrofuran derivatives (enabling a separation from the large amounts of normal fatty acids), F‐acids (F 3 , F 4 and F 6 ) were detected in rat food, correcting earlier results. Quantification of F‐acid intake with food and excretion of furandicarboxylic acids in the urine, suggested the possibility that the F‐acids are not produced de novo in the rat, but instead accumulate in tissue after nutritional intake.