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Geraniol interferes with membrane functions in strains of Candida and Saccharomyces
Author(s) -
Bard Martin,
Albrecht Mark R.,
Gupta Navyash,
Guynn Cynthia J.,
Stillwell William
Publication year - 1988
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535593
Subject(s) - geraniol , phospholipid , vesicle , bilayer , membrane fluidity , chemistry , dipalmitoylphosphatidylcholine , membrane , biophysics , fluorescence anisotropy , saccharomyces cerevisiae , biochemistry , biology , chromatography , yeast , phosphatidylcholine , essential oil
Geraniol, an olefinic terpene, was found to inhibit growth of Candida albicans and Saccharomyces cerevisiae strains. Geraniol was shown to enhance the rate of potassium leakage out of whole cells and also was shown by fluorescence polarization to increase C. albicans membrane fluidity. Biophysical studies using differential scanning calorimetry, fluorescence polarization and osmotic swelling of phospholipid vesicles demonstrated that geraniol decreased the phase‐transition temperature of dipalmitoylphosphatidylcholine vesicles, affected fluidity throughout the bilayer, particularly the central portion of the bilayers, and caused an increase in bilayer permeability to erythritol. Geraniol may have potential use as an antifungal agent.