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Effects of a platelet‐activating factor antagonist, CV‐6209, on Gastric mucosal lesions induced by ischemia‐reperfusion
Author(s) -
Yoshikawa Toshikazu,
Takahashi Shuji,
Naito Yuji,
Ueda Shigenobu,
Tanigawa Toru,
Yoshida Norimasa,
Kondo Motoharu
Publication year - 1992
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535589
Subject(s) - platelet activating factor , ischemia , chemistry , pharmacology , reperfusion injury , lipid peroxidation , antagonist , gastric mucosa , reactive oxygen species , superoxide , thiobarbituric acid , endogeny , immunology , receptor , medicine , stomach , biochemistry , antioxidant , enzyme
Recent research was shown that oxygen‐derived free radicals are involved in the pathogenesis of various diseases, including ischemia‐reperfusion injury. We have also reported that oxygen‐derived free radicals and lipid peroxidation may play an important role in gastric mucosal injury induced by ischemia‐reperfusion. The hypoxanthinexanthine oxidase system and neutrophils are considered important sources of oxygen‐derived free radicals in this process. In recent years, it also has been shown that serum platelet‐activating factor (PAF) levels increased during ischemia‐reperfusion, and that induction of superoxide generation by neutrophils is one of the important biological effects of PAF. In the present study, we examined the effect of CV‐6209, a specific PAF receptor antagonist, on gastric mucosal injury induced by ischemia‐reperfusion, to shed some light on the possible involvement of PAF in such lesions. CV‐6209 significantly attenuated the gastric mucosal injury induced by ischemia‐reperfusion, and inhibited both an increase of thiobarbituric acid reactive substances and a decrease of α‐tocopherol in gastric mucosa after ischemia‐reperfusion. However, CV‐6209 had no effect on gastric mucosal blood flow during ischemiano effect on gastric mucosal blood flow during ischemia‐reperfusion. These results suggest that endogenous PAF may play an important role in gastric mucosal injury induced by ischemia‐reperfusion, and that CV‐6209 exerts its beneficial effect mainly by inhibiting neutrophil superoxide production induced by PAF.