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Borage or primrose oil added to standardized diets are equivalent sources for γ‐linolenic acid in rats
Author(s) -
Raederstorff D.,
Moser U.
Publication year - 1992
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535582
Subject(s) - evening primrose oil , gamma linolenic acid , evening primrose , arachidonic acid , thromboxane , chemistry , phospholipid , polyunsaturated fatty acid , food science , linolenic acid , prostaglandin , fatty acid , thromboxane b2 , lipidology , medicine , endocrinology , biochemistry , biology , linoleic acid , platelet , membrane , enzyme
The aim of this study was to evaluate the effect of different doses and sources of dietary γ‐linolenic acid (GLA) on the tissue phospholipid fatty acid composition. Rats fed four different levels of GLA (2.3, 4.6, 6.4 and 16.2 g of GLA/kg diet) in the form of either borage oil or evening primrose oil during 6 wk were compared with animals fed corn oil. The levels of dihomo‐γ‐linolenic acid (DHLA) and GLA showed a significant dose‐related increase in liver, erythrocyte and aorta phospholipids. Moreover, the arachidonic acid/DHLA ratios in tissues decreased with increasing intake of dietary GLA. There was no significant difference in tissue GLA and DHLA levels within groups given equal amounts of dietary GLA either as borage oil or evening primrose oil. The amount of dietary GLA administered did not significantly influence prostaglandin E 2 production in stimulated aortic rings and thromboxane B 2 levels in serum; however, an increase in prostaglandin E 1 derived from DHLA was observed in the supernatants of stimulated aorta.