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Distribution and metabolism of hexadecylphosphocholine in mice
Author(s) -
Breiser A.,
Kim D. J.,
Fleer E. A. M.,
Damenz W.,
Drube A.,
Berger M.,
Nagel G. A.,
Eibl H.,
Unger C.
Publication year - 1987
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535556
Subject(s) - lipidology , clinical chemistry , distribution (mathematics) , metabolism , chemistry , biochemistry , mathematics , mathematical analysis
Distribution and metabolic fate of radiolabeled hexadecylphosphocholine (He‐PC) has been studied in mice. It is demonstrated that He‐PC is well‐absorbed from the intestinal tract, intravenous (IV) and oral administration lead to similar distributions throughout the body, the highest accumulation of radioactivity occurs in liver, lung and kidney, and the metabolic products are radioactive choline, phosphocholine and 1,2‐diacylphosphatidylcholine. The occurrence of these metabolites indicates that phospholipases C and D may be involved in He‐PC breakdown.