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Immunomodulatory and therapeutic properties of alkyl lysophospholipids in mice
Author(s) -
Talmadge James E.,
Schneider Mark,
Lenz Barbara,
Phillips Hamblin,
Long Cedric
Publication year - 1987
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535547
Subject(s) - in vivo , cytotoxicity , immunoadjuvant , chemistry , in vitro , pharmacology , macrophage , cytotoxic t cell , biochemistry , immunology , immune system , biology , microbiology and biotechnology
This paper describes the immunomodulatory and therapeutic properties of the alkyl lysophospholipids [ALP; 1‐ O ‐octadecyl‐2‐ O‐rac ‐glycero‐3‐phosphocholine (ET‐18‐OCH 3 )]. ALP was able to activate macrophages both in vitro and in vivo as well as to act as an immunoadjuvant for syngeneic tumor vaccines. However, ALP appeared to be transferred, at least in part, to the macrophage membrane, and some of the tumoricidal macrophage‐activating properties seem to be associated with the direct cytotoxic effect of membrane‐released ALP. ALP also had some therapeutic activity for experimental and spontaneous metastases, requiring administration three but not two times weekly at near‐toxic doses; this suggests that at least some of its therapeutic activity is due to direct cytotoxicity.