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Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion
Author(s) -
Blitterswijk Wim J.,
Hilkmann Henk,
Storme Guy A.
Publication year - 1987
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535537
Subject(s) - membrane , membrane fluidity , chemistry , phospholipid , cell , lipidology , cell membrane , clinical chemistry , biochemistry , biophysics , microbiology and biotechnology , biology
Tumor cells grown in the presence of 1‐ O ‐alkyl‐2‐ O ‐methylglycero‐3‐phosphocholine (AMG‐PC) accumulated this ether lipid in their membranes. Depending on the cell type and the dose of the compound, up to 17% of the total phospholipids of the purified plasma membranes consisted of authentic AMG‐PC. Extensive incorporation of the agent resulted in a decrease in plasma membrane fluidity and inhibition of tumor cell invasiveness in embryonic chick heart fragments. The extent of AMG‐PC incorporation and fluidity change was not strictly correlated with the degree to which tumor cell invasion was inhibited.