Premium
Stimulation of liver growth and DNA synthesis by glucosylceramide
Author(s) -
Datta Subhash C.,
Radin Norman S.
Publication year - 1988
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535529
Subject(s) - cerebroside , dna synthesis , glucocerebroside , stimulation , cell growth , clinical chemistry , biochemistry , lipidology , enzyme , ornithine decarboxylase , chemistry , thymidine , biology , endocrinology , dna , glucocerebrosidase
The nature of the growth‐stimulating effect of glucosylceramide was studied. Mice were injected intraperitoneally with emulsified glucosylceramide and conduritol B epoxide, an inhibitor of cerebroside glucosidase. Within one or two days, the liver grew 18–24%, as reported. Two enzymes involved in DNA synthesis also increased more than the weight. The total liver activity of thymidine kinase increased 46–73%, and the total activity of ornithine decarboxylase increased as much as 101%. It is suggested that elevated liver levels of glucocerebroside stimulate cell proliferation through a relatively direct mechanism.