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Compensatory mechanisms in erythrocyte lipids in patients with atherosclerosis
Author(s) -
Michalak Jerzy,
Kadziolka Adam,
Pruszkowska Romualda,
Ledwozyw Andrzej,
Madejczyk Andrej
Publication year - 1988
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535523
Subject(s) - sphingomyelin , phospholipid , phosphatidylcholine , phosphatidylinositol , cholesterol , lipidology , clinical chemistry , chemistry , biochemistry , palmitic acid , medicine , endocrinology , fatty acid , biology , membrane , kinase
The quantitative coposition of phospholipids and fatty acids of erythrocytes was investigated in patients with atherosclerosis. It was stated that the erythrocyte lipids of atherosclerotic patients contained smaller quantitities of phosphatidylcholine and phosphatidylinositol, a significantly larger quantity of sphingomyelin, and higher sphingomyelin/phosphatidylcholine and cholesterol/phospholipid ratios. The existence of compensatory changes was stated, which was evident in the reduction of palmitic and stearic acids and the increase of linoleic and eicosatrienoic acids in erythrocyte phospholipids. These changes in fatty acid composition probably cause minimal changes in the membrane fluidity indiced by an increased cholesterol/phospholipid and sphingomyelin/phosphatidylcholine ratios. This paper was the first evidence of occurrence of those changes in erythrocytes during spontaneous atherosclerosis in human