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Changes in lipids in liver and serum of rats fed a histidine‐excess diet or cholesterol‐supplemented diets
Author(s) -
Ohmura Eri,
Aoyama Yoritaka,
Yoshida Akira
Publication year - 1986
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535406
Subject(s) - cholesterol , medicine , endocrinology , histidine , lipidology , triglyceride , clinical chemistry , basal (medicine) , high density lipoprotein , biology , lipoprotein , blood lipids , chemistry , biochemistry , amino acid , insulin
The influence of dietary excess (5%) L‐histidine on serum and liver lipids was examined in rats. Feeding a histidine‐excess diet for 3, 6, 14 or 30 days caused growth retardation, hepatomegaly and decreased liver lipids throughout the period of the experiment. Hypercholesterolemia was observed after feeding a histidine‐excess diet for 6 days; then serum cholesterol continuously increased for 30 days. Serum triglyceride on day 30 in rats fed the histidine‐excess diet showed a significant decrease compared to rats fed the basal diet. Serum phospholipids of rats fed the histidine‐excess diet for 7 or 14 days showed a significant increase compared to rats fed the basal diet. When rats were fed a basal, histidine‐excess or cholesterol‐supplemented diet (0.5% and 1.0% cholesterol) for 6 days, the distribution of serum high density (HDL), low density (LDL) and very low density lipoprotein cholesterol in rats fed the histidine‐excess diet was similar to that of rats fed the basal diet, whereas LDL‐cholesterol increased and HDL‐cholesterol decreased in rats fed the cholesterol‐supplemented diet.