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Intestinal absorption and fecal excretion of 5,6α‐epoxy‐5α‐cholesta‐3β‐ol by the male wistar rat
Author(s) -
Bascoul J.,
Domergue N.,
Mourot J.,
Debry G.,
Paulet A. Crastes
Publication year - 1986
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535405
Subject(s) - feces , lipidology , excretion , clinical chemistry , absorption (acoustics) , epoxy , chemistry , medicine , biology , endocrinology , biochemistry , microbiology and biotechnology , organic chemistry , physics , optics
The intestinal absorption of 5,6α‐epoxy‐5α‐cholesta‐3β‐ol, an oxysterol formed by cholesterol autoxidation, has been evaluated in the male Wistar rat. Measurement of the 14 C/ 3 H ratio in the serum (by the method of Zilversmit and Hugues) and in the feces showed that a large proportion of the epoxide was absorbed. Epoxide clearance from the blood was very rapid, but its excretion in the stool continued for several days, corresponding to the fraction of the epoxide stored in the animal.