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Comparative study of the blood pressure effects of four different vegetable fats on young, spontaneously hypertensive rats
Author(s) -
Hoffmann P.,
Block H. U.,
Beitz J.,
Taube Ch.,
Forster W.,
Wortha P.,
Singer P.,
Naumann E.,
Heine H.
Publication year - 1986
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535403
Subject(s) - linseed oil , polyunsaturated fatty acid , chemistry , linoleic acid , sunflower oil , alpha linolenic acid , gamma linolenic acid , sunflower seed , food science , fatty acid , medicine , biochemistry , endocrinology , docosahexaenoic acid , biology , sunflower , agronomy
Following the suckling period, four groups of male four‐week‐old spontaneously hypertensive rats (SHR) were fed semisynthetic diets with 14% (by weight) of either sunflower seed oil [46% 18∶2(n−6); linoleic acid (LA)‐rich], linseed oil [62.5% 18∶3(n−3)+12.9% 18∶2(n−6); α‐linolenic acid (LNA)‐rich], evening primrose oil [9.2% 18∶3(n−6)+71% 18∶2(n−6); γ‐linolenic acid (LNA)‐rich] or hydrogenated palm kernel fat [1.5% 18∶2(n−6); polyunsaturated fatty acid (PUFA)‐deficient], respectively, up to an age of 18 wk. All diets enriched with PUFA provoked an attenuation of hypertension development. The effect was lowest in the LA‐rich group and highest in the γ‐LNA‐rich group. Differences in fatty acid composition of renal phospholipids between groups reflect the fatty acids present in the respective dietary fats. Renomedullary production of PGF 2α was significantly reduced in α‐LNA‐rich and slightly diminished in γ‐LNA‐rich fed rats. Aortic formation of 6‐keto‐PGF 1α and TXB 2 was increased in animals fed the γ‐LNA‐rich diet. Thus, the attenuation of hypertension development cannot be explained only by changes in prostanoid formation. Other mechanisms possibly involved should be pursued.