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The effects of fasting and streptozotocin diabetes on the triglyceride lipase activity of rat liver plasma membranes
Author(s) -
Nomura Takahide,
Iguchi Akihisa,
Matsunaga Hitoshi,
Sakamoto Nobuo
Publication year - 1982
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535387
Subject(s) - medicine , endocrinology , streptozotocin , clinical chemistry , insulin , lipidology , triglyceride lipase , triglyceride , diabetes mellitus , lipase , membrane , chemistry , enzyme assay , enzyme , cholesterol , biochemistry
Abstract The activity of hepatic triglyceride lipase (H‐TGL) of plasma membranes isolated from rat liver is shown to be reduced by fasting. Refeeding restores the enzyme activity. The suppressed activity of H‐TGL in streptozotocin diabetic rats is restored by insulin treatment. The behavior of the enzyme activites in both situation coincides with that of plasma insulin levels. The results suggest that the H‐TGL of rat liver plasma membranes is under hormonal regulation by insulin.