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Lysophosphatidylcholine acyltransferases activity during experimental cholelithiasis
Author(s) -
Allen Rutledge F.,
Hickman Donn M.,
Dunn Joceyln J.,
Frey Charles F.,
Matson Robert S.
Publication year - 1981
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535337
Subject(s) - lysophosphatidylcholine , gallbladder , acyltransferases , lipidology , cholesterol , medicine , clinical chemistry , chemistry , acyltransferase , gastroenterology , biochemistry , endocrinology , phospholipid , enzyme , phosphatidylcholine , membrane , biosynthesis
The accumulation of (1‐palmitoyl)lysophosphatidylcholine, lysolecithin, in gallbladder bile was observed during the first week of cholesterol‐induced experimentals cholelithiasis using the prairie dog model for cholesterol gallstone formation. Gallbladder fluid transport function decreased as bile lysolecithin concentration increased. These observations suggest that lysolecithin play an important, early role in the etiology of gallstone disease. Furthermore, the relative activities of hepatic and gallbladder mucosa lysophosphatidylcholine acyltransferase and acylcoenzyme A hydrolases may be responsible for the turnover of gallbladder bile lysolecithin.