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Effect of age and cholestyramine feeding on rat liver 3‐hydroxy‐3‐methyl glutaryl CoA reductase, sterol carrier protein 1 and sterol carrier protein 2 activities
Author(s) -
Morin Robert J.,
Brun Michael J.,
Srikantaiah M. V.
Publication year - 1982
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535333
Subject(s) - sterol , cholestyramine , squalene , microsome , reductase , cholesterol , cytosol , enzyme , clinical chemistry , biochemistry , medicine , endocrinology , microsoma , biology , sterol regulatory element binding protein , chemistry
The rate of formation of sterol from squalene in livers from suckling rats was less than one‐third that of adults. This difference was due to a lesser activity of microsomal enzymes in the suckling rat livers, and not to any difference in cytosolic sterol carrier protein 1. The microsomal enzymes and sterol carrier protein 2 of the cytosol required for the conversion 7‐dehydrocholesterol to cholesterol were both lower in suckling rats compared to adults. Both those activities paralleled the differences in HMG‐CoA reductase activities between suckling and adult rats. Feeding of cholestryamine to adult rats increased the activities of the microsomal enzymes, sterol carrier protein 1 and sterol carrier protein 2 involved in the conversion of squalene to cholesterol.