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The metabolism of lithocholic acid and lithocholic acid‐3‐α‐sulfate by human fecal bacteria
Author(s) -
Borriello S. P.,
Owen R. W.
Publication year - 1982
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535328
Subject(s) - lithocholic acid , chemistry , biochemistry , bile acid , metabolism , cholic acid , sulfate , bacteria , microbial metabolism , biology , organic chemistry , genetics
Both lithocholic acid and lithocholic acid‐3α‐sulfate are metabolized by mixed fecal bacteria and by pure strains of the genus Clostridium . Mixed fecal bacteria metabolized lithocholic acid to 3‐ketolithocholic acid; lithocholic acid‐3α‐sulfate was metabolized to isolithocholic acid, 5β‐cholanic acid and Δ 3 ‐cholenic acid under both aerobic and anaerobic conditions. The results indicate that a specific genus, the Clostridium , has a primary role in the metabolism of lithocholic acid‐3α‐sulfate to Δ 3 ‐cholenic acid