The metabolism of lithocholic acid and lithocholic acid‐3‐α‐sulfate by human fecal bacteria | Zendy

Borriello S. P. | Zendy; Owen R. W. | Zendy

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The metabolism of lithocholic acid and lithocholic acid‐3‐α‐sulfate by human fecal bacteria

Author(s) -

Borriello S. P.,

Owen R. W.

Publication year - 1982

Publication title -

lipids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 120

eISSN - 1558-9307

pISSN - 0024-4201

DOI - 10.1007/bf02535328

Subject(s) - lithocholic acid , chemistry , biochemistry , bile acid , metabolism , cholic acid , sulfate , bacteria , microbial metabolism , biology , organic chemistry , genetics

Both lithocholic acid and lithocholic acid‐3α‐sulfate are metabolized by mixed fecal bacteria and by pure strains of the genus Clostridium . Mixed fecal bacteria metabolized lithocholic acid to 3‐ketolithocholic acid; lithocholic acid‐3α‐sulfate was metabolized to isolithocholic acid, 5β‐cholanic acid and Δ 3 ‐cholenic acid under both aerobic and anaerobic conditions. The results indicate that a specific genus, the Clostridium , has a primary role in the metabolism of lithocholic acid‐3α‐sulfate to Δ 3 ‐cholenic acid

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