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Uptake of artificial model remnant lipoprotein emulsions by the perfused rat liver
Author(s) -
Redgrave Trevor G.,
Maranhao Raul C.,
Tercyak Anna M.,
Lincoln Elizabeth C.,
Brunengraber Henri
Publication year - 1988
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535288
Subject(s) - lipidology , clinical chemistry , lipoprotein , chemistry , biochemistry , cholesterol
In comparison with their precursor lipoproteins, the remnants of the triacylglycerol‐rich lipoproteins are reduced in contents of triacylglycerols and apolipoproteins AI and AIV, whereas the contents of cholesterol (free and esterified) and apolipoprotein E are increased. In this study, lipid emulsion models of remnant lipoproteins were used to explore which of these factors are necessary for physiological rates of remnant uptake by the perfused rat liver. Uptake rates of lipid emulsion models of remnant lipoproteins in the presence of apolipoprotein E were similar to in vivo uptake rates.