Premium
Tissue fatty acid changes and tumor incidence in C3H mice ingesting cottonseed oil
Author(s) -
Tinsley Ian J.,
Wilson Glenn,
Lowry Robert R.
Publication year - 1982
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535186
Subject(s) - cottonseed , cottonseed oil , cyclopropene , lipidology , clinical chemistry , fatty acid , stearate , chemistry , biochemistry , food science , medicine , biology , endocrinology , organic chemistry
The incidence of spontaneous mammary tumors in C3H mice at 35 wk was higher in mice fed rations containing cottonseed oil than in mice fed fats of comparable fatty acid composition. The time to 50% (T 50 ) incidence was also shorter in the first group. The fatty acid composition of tissue lipids from mice fed the cottonseed oil showed changes indicating the presence of cyclopropene fatty acids‐higher levels of saturates and lower oleate/stearate and palmitoleate/palmitate ratios. A possible association between the development of a spontaneous mammary tumor in the C3H mouse and the presence of cyclopropene fatty acids in the cottonseed oil is indicated.