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Oral contraceptive and platelet lipid biosynthesis in female rats: Dose‐response relationship
Author(s) -
Ciavatti M.,
Davenas E.,
Michel G.,
Renaud S.
Publication year - 1982
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535185
Subject(s) - biosynthesis , platelet , lipidology , lanosterol , lynestrenol , clinical chemistry , medicine , cholesterol , endocrinology , chemistry , sterol , biochemistry , biology , population , research methodology , gene , environmental health , family planning
Female rats were treated with different doses of an oral contraceptive (ethinyl estradiol + lynestrenol) and lipid biosynthesis was studied in blood platelets by acetate incorporation into different fractions separated by thin layer chromatography. A marked increase in lipid biosynthesis was observed, especially in the sterol fractions (cholesterol and lanosterol‐dihydrolanosterol). It was dose‐dependent, observed after a lag‐phase, maximal in 3 days and normalized in 8 days. Thus, the oral contraceptive studied here appears to modify platelet lipid biosynthesis for the entire life of the platelets.