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Essential and nonessential fatty acid oxidation in mice bearing Ehrlich ascites carcinoma
Author(s) -
Ookhtens Murad,
Baker Nome
Publication year - 1982
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535177
Subject(s) - clinical chemistry , ehrlich ascites carcinoma , chemistry , ascites , medicine , lipidology , oxidative phosphorylation , fatty acid , bearing (navigation) , endocrinology , biochemistry , in vitro , cartography , geography
We tested the hypothesis that mobilized (essential) free fatty acids (FFA) are spared from oxidation in cancer‐bearing animals. We injected tracers [1‐ 14 C]linoleate, [1‐ 14 C] palmitate and NaH 14 CO 3 intravenously as single rapid doses in separate groups of mice bearing Ehrlich ascites tumor (EAT) and controls, and measured breath 14 CO 2 . The data from NaH 14 CO 3 injections were used to develop kinetic, compartmental models of the HCO 3 − ‐CO 2 systems. These models were integrated with our earlier model of plasma FFA turnover for control and EAT‐bearing mice. The integrated multicompartmental models were then fitted to breath 14 CO 2 data from mice injected with tracer FFA to compute the rates of FFA oxidation. FFA were not spared from an oxidative fate in our cancer‐bearing vs normal animals; moreover, essential FFA were not preferentially spared from oxidation compared to nonessential FFA in the cancer‐bearing mice.