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Dipyridamole inhibits lipid peroxidation and scavenges oxygen radicals
Author(s) -
Iuliano L.,
Violl F.,
Ghiselli A.,
Alessandri C.,
Balsano F.
Publication year - 1989
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535151
Subject(s) - dipyridamole , deoxyribose , chemistry , lipid peroxidation , radical , xanthine oxidase , superoxide , arachidonic acid , linoleic acid , biochemistry , pharmacology , antioxidant , hydroxyl radical , fatty acid , enzyme , medicine , dna
Dipyridamole incubated in vitro in systems which peroxidize fatty acids inhibited arachidonic acid, gammalinolenic acid and linoleic acid peroxidation. In the xanthine‐xanthine‐oxidase system, which produces superoxide anion, dipyridamole inhibited the reduction of cytochrome‐C in a dose‐dependent fashion. In systems generating hydroxyl radicals, dipyridamole reduced deoxyribose degradation in a dose‐dependent manner. The study suggests that dipyridamole inhibits lipid peroxidation, probably by scavening oxygen free radicals.