Premium
Hypercholesterolemia in rats: Combined effect of high cholesterol diet and female sex steroids
Author(s) -
Fischer G. M.,
Swain M. L.
Publication year - 1982
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535099
Subject(s) - lipidology , medicine , endocrinology , clinical chemistry , cholesterol , endogeny , hormone , steroid , thiouracil , biology , thyroid
The influence of estradiol and a contraceptive steroid combination on plasma cholesterol was studied in female rats on both normal and high‐cholesterol diets which did not contain thiouracil. The high‐cholesterol diet resulted in moderate hypercholesterolemia without weight loss, even with prolonged feeding. Hypercholesterolemia was markedly accentuated in the presence of either endogenous or exogenous sex hormones.