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Sterols and their biosynthesis in some freshwater bivalves
Author(s) -
Popov S.,
Stoilov I.,
Marekov N.,
Kovachev G.,
Andreev St.
Publication year - 1981
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535061
Subject(s) - lipidology , biosynthesis , clinical chemistry , chemistry , biology , zoology , biochemistry , environmental chemistry , enzyme
A number of free sterols and sterol esters of three freshwater mussels was separated and identified. A slow rate of biosynthesis de novo of sterols was demonstrated in Anodonta cygnea . Injected cholesterol was found to undergo esterification, oxidation, Δ 22 ‐dehydrogenation and C‐24 alkylation. Methyl‐[ 14 C]methionine was proved to be incorporated in C‐24 alkylsterols. Abnormally large amounts of cholesterol injected in A. cygnea were metabolized toward restoration of the normal composition of sterols. This was achieved by intensified metabolism of cholesterol, mainly by conjugation, oxidation and Δ 22 ‐dehydrogenation.