Premium
Transformation of arachidonic acid into monohydroxy‐eicosatetraenoic acids by mouse peritoneal macrophages
Author(s) -
Rabinovitch Hélène,
Durand Jacqueline,
Rigaud Michel,
Mendy Francois,
Breton JeanChristian
Publication year - 1981
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535050
Subject(s) - arachidonic acid , chromatography , chemistry , lipidology , clinical chemistry , mass spectrometry , metabolism , liquid chromatography–mass spectrometry , biochemistry , enzyme
Mouse peritoneal macrophages synthesize 6 monohydroxylated eicosatetraenoic acids when incubated with exogenous arachidonic acid. These compounds were identified by chromatographic techniques (high pressure liquid chromatography and high efficiency glass capillary column gas chromatography and mass spectrometry. The chromatographic and spectrometric data are presented. These results show that peritoneal macrophages constitute one of the best systems to study in evaluating the metabolism of oxygenated products of arachidonic acid.