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Potential bile acid metabolites: IV. Inversion of 7α‐hydroxyl; ursodeoxycholic acid
Author(s) -
Iida Takashi,
Taneja Hans R.,
Chang Frederic C.
Publication year - 1981
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535043
Subject(s) - ursodeoxycholic acid , chenodeoxycholic acid , chemistry , ketone , bile acid , potassium , lipidology , yield (engineering) , clinical chemistry , organic chemistry , biochemistry , materials science , metallurgy
A new method for inversion of chenodeoxycholic to ursodeoxycholic acid which does not involve an intermediary ketone is described. Methyl chenodeoxycholate‐3‐cathylate‐7‐mesylate undergoes a mild reaction with potassium superoxide‐18‐crown ether‐6 in DMSO to give ursodeoxycholic acid in good yield.