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Absence of cholesterogenesis regulation in the liver and prostate of the BIO 87.20 hamster
Author(s) -
Schaffner Carl P.,
Brill David R.,
Singhal Anil K.,
Bonner Daniel P.,
Goldstein Neil I.,
Wang Geng M.
Publication year - 1981
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535039
Subject(s) - hamster , cholesterol , clofibrate , mesocricetus , medicine , biology , endocrinology , in vivo , clinical chemistry , prostate , lipidology , microbiology and biotechnology , cancer
Normal, adult golden Syrian hamsters and the inbred stain BIO 87.20 Syrian hamsters were maintained on either control, cholesterol, candicidin or clofibrate diets for time periods of up to 4 months. The ventral prostate gland in both species was found to synthesize cholesterol at a greater rate than the liver. Also, our results show that, while hepatic cholesterol synthesis in the normal Syrian hamster is under feedback control with dietary cholesterol, hepatic cholesterol synthesis in the BIO 87.20 hamster, and prostatic cholesterol synthesis in either species, is under no such control. This apparent regulatory defect in the BIO 87.20 hamster, which results in a dramatic accumulation of cholesterol in the liver and serum, renders this animal a potentially valuable in vivo model for the study of cholesterol‐related disorders.