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Effect of water mobility on lateral diffusion of phospholipids in liposomes
Author(s) -
Wu WenGuey,
Huang ChingHsien
Publication year - 1981
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535036
Subject(s) - phospholipid , diffusion , chemistry , liposome , phosphatidylcholine , lamellar structure , lateral diffusion , chemical physics , thermodynamics , analytical chemistry (journal) , chromatography , crystallography , membrane , biochemistry , physics
Recently, several studies have shown that the rate of lateral diffusion of liquid‐crystalline phospholipids in various phospholipid/water lamellar systems depends markedly on the hydration over the water content of 15–40 w/w%. In this paper, we calculated the change in lipid lateral diffusion as a function of water content according to the theory of Brownian motion in thin sheets developed by Saffman and Delbrück. These calculations, based on experimental data of lipid dimensions and bulk water diffusion coefficients obtained for the egg phosphatidylcholine/water system at various water contents, clearly indicate that the dependence of lipid lateral diffusion on the hydration can be attributed primarily to the change in bulk water mobility in the multilamellar phospholipid/water system.