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Lactoperoxidase‐catalyzed lodination of arachidonic acid: Formation of macrolides
Author(s) -
Boeynaems J. M.,
Reagan D.,
Hubbard W. C.
Publication year - 1981
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535024
Subject(s) - lactoperoxidase , chemistry , hydrogen peroxide , arachidonic acid , lactone , catalysis , mass spectrometry , nuclear magnetic resonance spectroscopy , iodide , organic chemistry , stereochemistry , peroxidase , chromatography , enzyme
In the presence of iodide and hydrogen peroxide, lactoperoxidase catalyzed the conversion of arachidonic acid into several iodinated products; the major one was previously identified as an iodo‐δ‐lactone. Two minor and less polar products have now been characterized as 15‐iodo‐14‐hydroxyeicosatrienoic acid, ω‐lactone and 14‐iodo‐15‐hydroxyeicosatrienoic acid, ω‐lactone, on the basis of 125 I incorporation, mass spectrometry, proton magnetic resonance spectroscopy and chemical modifications.