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Inhibition of hepatic cholesterol biosynthesis by chloroquine
Author(s) -
Beynen Anton C.,
Van Der Molen Ate J.,
Geelen Math J. H.
Publication year - 1981
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535017
Subject(s) - chloroquine , biosynthesis , lipidology , clinical chemistry , cholesterol , biochemistry , cytosol , chemistry , biology , pharmacology , enzyme , malaria , immunology
Chloroquine is shown to be a potent inhibitor of cholesterol biosynthesis by isolated rat hepatocytes. Half‐maximal inhibition of cholesterogenesis occurs at ca. 10μM chloroquine. Chloroquine does not affect fatty acid synthesis by isolated hepatocytes. This suggests that chloroquine acts on the cholesterol biosynthetic pathway beyond the cytosolic acetyl‐CoA branchpoint of cholesterol and fatty acid synthesis.