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Effect of polyestradiol on lecithin:cholesterol acyltransferase in male and female rats
Author(s) -
Gandarias J. M.,
Lacort M.,
Ochoa B.,
Quiroga M.
Publication year - 1981
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535013
Subject(s) - endocrinology , lecithin—cholesterol acyltransferase , medicine , cholesterol , clinical chemistry , lipidology , lecithin , sterol o acyltransferase , chemistry , acyltransferase , reverse cholesterol transport , specific activity , biology , enzyme , biochemistry , lipoprotein
The effects of two doses of polyestradiol phosphate on lecithin:cholesterol acyltransferase activity and on liver and plasma cholesterol levels have been studied on female and male rats. Both treatments increased the hepatic content of esterified cholesterol, but the LCAT activity expressed as a percentage of cholesterol esterification was unaltered. The progress of esterification was not affected by the administration of the hormone. The LCAT activity in terms of the initial rate of esterification was decreased by the high dose of estradiol. This decrease was associated with a reduction of free plasma cholesterol level, as there is a significant positive correlation between these two parameters. The findings suggest that the increased esterified cholesterol in liver of estradiol‐treated rats is not mediated by an alteration in the LCAT activity.