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Enzymatic formation of cholesteryl ester from cholesterol by gallbladder mucosa
Author(s) -
Neiderhiser Dewey H.
Publication year - 1981
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02535000
Subject(s) - lipidology , clinical chemistry , cholesterol , cholesteryl ester , gallbladder , enzyme , chemistry , biochemistry , medicine , lipoprotein
The formation of cholesteryl ester from cholesterol and acyl CoA catalyzed by the enzyme acyl CoA: cholesterol acyltransferase (EC 2.3.1.26) was studied in guinea pig gallbladder mucosa homogenate and the subcellular fractions. The enzymatic activity was enriched in the microsomal fraction. Highest activity was observed with palmitoyl, stearoyl or oleoyl CoA as substrate. Lowest activity was observed with linoleoyl CoA. These data elucidate one mechanism for the formation of cholesteryl ester from cholesterol by the gallbladder wall.