Premium
Phospholipid acyl group composition in normal and tumoral nerve cells in culture
Author(s) -
Montaudon Danièle,
Louis JeanClaude,
Robert Jacques
Publication year - 1981
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534952
Subject(s) - phospholipid , clinical chemistry , cell culture , cell , lipidology , nerve cells , membrane , biochemistry , polyunsaturated fatty acid , fatty acid , composition (language) , cell type , cell membrane , chemistry , neurochemistry , biology , microbiology and biotechnology , neurology , genetics , neuroscience , linguistics , philosophy
We have studied the fatty acid composition of total phosphoglycerides from various types of nerve cells in culture. Primary cell cultures were compared with tumoral cell strains. Glial cells exhibited no characteristic pattern when compared to neurons. Tumoral cell phosphogly cerides contained much higher levels of octadecenoic acid and lower levels of C‐20 to C‐22 polyunsaturated fatty acids than normal cell phosphoglycerides. This observation seems to be a general feature in tumoral cell membranes. It could be of interest in respect to the membrane fluidity of cancer cells.