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The lipid composition of human liver microsomes
Author(s) -
Waskell Lucy,
Koblin Donald,
CanovaDavis Eleanor
Publication year - 1982
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534948
Subject(s) - microsome , phospholipid , phosphatidylethanolamine , sphingomyelin , phosphatidylcholine , phosphatidylserine , biochemistry , docosapentaenoic acid , clinical chemistry , composition (language) , phosphatidylinositol , polyunsaturated fatty acid , docosahexaenoic acid , arachidonic acid , lipidology , chemistry , biology , cholesterol , fatty acid , enzyme , linguistics , philosophy , kinase , membrane
Abstract The lipid composition of human liver microsomes isolated from liver biopsy samples obtained at abdominal surgery has been determined. Human liver microsomal phospholipid is composed of 49% phosphatidylcholine, 31% phosphatidylethanolamine, 14% phosphatidylserine+phosphatidylinositol and 6% sphingomyelin, very similar to the phospholipid composition of rat liver microsomes. The fatty acid composition of human liver microsomes is remarkable only for its content of polyunsaturated fatty acids, with 20% of the fatty acids consisting of arachidonic, docosatetraenoic, docosapentaenoic and docosahexaenoic acids. This value contrasts with 33% in rats and 9% in rabbits. The molar cholesterol/phospholipid ratio in human liver microsomes is 0.069, similar to the ratio in rat and rabbit microsomes.