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The synthesis in vivo of choline and ethanolamine phosphoglycerides in different brain areas during aging
Author(s) -
Gaiti Alberto,
Brunetti Marina,
Piccinin Gian Luigi,
Woelk Helmut,
Porcellati Giuseppe
Publication year - 1982
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534944
Subject(s) - lipidology , in vivo , ethanolamine , clinical chemistry , choline , neurochemistry , chemistry , biochemistry , neuroscience , biology , neurology , microbiology and biotechnology
The biosynthesis of choline and ethanolamine phosphoglycerides was tested in vivo in different brain areas of the rat during aging. Mixtures of [2− 3 H] glycerol and [ Me ‐ 14 C] choline or [2‐ 3 H] glycerol and [2‐ 14 H] ethanolamine were injected into lateral ventricle of the brain as lipid precursors and their incorporation into corresponding phospholipid was examined. A significant decrease of synthesis of both phosphoglycerides takes place in cerebral cortex and in the striatum, and is already apparent at 9 months of age with no further decrease or change therafter. No significant change takes place in the cerebellum. The unchanged absorption of injected water‐soluble precursors, together with the lack of any significant change of phospholipid/protein ratio in all examined brain areas, suggests that the incorporation of both glycerol and nitrogen bases are affected by aging.