Premium
Thromboxane B 2 biosynthesis and phospholipids hydrolysis in platelets from hypercholesterolemic rabbits
Author(s) -
Kawaguchi H.,
Ishibashi T.,
Imai Y.
Publication year - 1981
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534919
Subject(s) - platelet , lipidology , biosynthesis , thromboxane , clinical chemistry , chemistry , hydrolysis , thromboxane a2 , biochemistry , platelet aggregation , chromatography , medicine , enzyme
Thromboxane B 2 biosynthesis from arachidonic acid was increased in platelets from hypercholesterolemic rabbits. The enzymic activity of phospholipase A 2 which releases arachidonic acid, the precursor for the biosynthesis of thromboxane B 2 , showed hardly any change in hypercholesterolemic platelets. Phospholipase C and diglyceride lipase activities also were not changed in platelets from hypercholesterolemic rabbits. Furthermore, phospholipid concentration in platelets were not increased in this state. Thus, we conclude that the supply of precursor for thromboxane B 2 biosynthesis was not increased in platelets from hypercholesterolemic rabbits as compared to controls. These results suggest that the enzyme activity of thromboxane B 2 biosynthesis may be enhanced in platelets from hypercholesterolemic rabbits.