Response of Drosophila  to cis ‐ and trans ‐22‐dehydrocholesterol II. Ability of sterols other than cholesterol to overcome the toxicity of the trans  isomer | Zendy

Kircher Henry W. | Zendy; Rosenstein Fumiko U. | Zendy; Fogleman James C. | Zendy

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Response of Drosophila to cis ‐ and trans ‐22‐dehydrocholesterol II. Ability of sterols other than cholesterol to overcome the toxicity of the trans isomer

Author(s) -

Kircher Henry W.,

Rosenstein Fumiko U.,

Fogleman James C.

Publication year - 1984

Publication title -

lipids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 120

eISSN - 1558-9307

pISSN - 0024-4201

DOI - 10.1007/bf02534803

Subject(s) - desmosterol , drosophila (subgenus) , sterol , cholesterol , biology , clinical chemistry , drosophila pseudoobscura , chemistry , biochemistry , gene

Four species of Drosophila were tested, for two generations, for viability on media containing 13 different C 27 , C 28 and C 29 sterols with and without trans ‐22‐dehydrocholesterol. Only cholesterol was effective for overcoming the toxic effect of the rans derivative for all 4 species. The species varied in their ability to use the 13 sterols for growth, maturation and reproduction for 2 generations. The most tolerant species. D. pseudoobscura , could use 11 of the 13 sterols for structural and hormonal functions, whereas the most sensitive species, D. mettleri , could survive adequately on only 4 and less than adequately on another 3 of the 13 compounds. Desmosterol could not be used by any species, even for 1 generation.

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