Premium
Response of Drosophila to cis ‐ and trans ‐22‐dehydrocholesterol II. Ability of sterols other than cholesterol to overcome the toxicity of the trans isomer
Author(s) -
Kircher Henry W.,
Rosenstein Fumiko U.,
Fogleman James C.
Publication year - 1984
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534803
Subject(s) - desmosterol , drosophila (subgenus) , sterol , cholesterol , biology , clinical chemistry , drosophila pseudoobscura , chemistry , biochemistry , gene
Four species of Drosophila were tested, for two generations, for viability on media containing 13 different C 27 , C 28 and C 29 sterols with and without trans ‐22‐dehydrocholesterol. Only cholesterol was effective for overcoming the toxic effect of the rans derivative for all 4 species. The species varied in their ability to use the 13 sterols for growth, maturation and reproduction for 2 generations. The most tolerant species. D. pseudoobscura , could use 11 of the 13 sterols for structural and hormonal functions, whereas the most sensitive species, D. mettleri , could survive adequately on only 4 and less than adequately on another 3 of the 13 compounds. Desmosterol could not be used by any species, even for 1 generation.