Premium
Inhibition of human lecithin cholesterol acyltransferase by monoterpenes
Author(s) -
Cooney Robert V.,
Nemhauser Jefferey,
Morin Robert J.
Publication year - 1984
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534791
Subject(s) - sterol o acyltransferase , chemistry , clinical chemistry , lecithin , cholesterol , enzyme , lipidology , biochemistry , acyltransferase , food science , chromatography , monoterpene , ingredient , lipoprotein
The lecithin‐cholesterol acyltransferase activity of human plasma was found to be inhibited by Rowachol, a proprietary mixture of pure monoterpenes. Menthol, the major ingredient in Rowachol (32%), and a number of other monoterpenes were found to inhibit the enzyme independently. Concentrations of monoterpenes required to achieve 50% inhibition were of the same order of magnitude as the cholesterol concentration present in the reaction mixture.