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Tissue phospholipid fatty acid composition in the diabetic rat
Author(s) -
Huang Y. S.,
Horrobin D. F.,
Manku M. S.,
Mitchell J.,
Ryan M. A.
Publication year - 1984
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534790
Subject(s) - clinical chemistry , phospholipid , arachidonic acid , lipidology , linoleic acid , endocrinology , medicine , fatty acid , kidney , diabetes mellitus , streptozotocin , chemistry , biochemistry , biology , enzyme , membrane
Tissue phospholipid fatty acid compositions in streptozotocin‐induced diabetic rats were studied. The major changes in liver, plasma, erythrocyte and heart were increased proportions of linoleic and dihomo‐γ‐linolenic acids and a decreased proportion of aracchidonic acid. The latter was not significantly changed in phospholipids of kidney, adrenal gland and testis. Skin fatty acids in diabetic rats showed an increase in the proportion of arachidonic acid and a reduction in the proportion of linoleic acid. The fatty acid desaturating activity in diabetes may be regulated differently in different tissues.