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The effect of dihydroergotoxine on lipid peroxidation in vitro
Author(s) -
Koréh Kinga,
Seligman Myron L.,
Demopoulos Harry B.
Publication year - 1982
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534658
Subject(s) - lipid peroxidation , cerebral blood flow , thiobarbituric acid , chemistry , in vitro , liposome , diltiazem , lipidology , pharmacology , cerebral cortex , antioxidant , clinical chemistry , biochemistry , medicine , anesthesia , organic chemistry , calcium
Dihydroergotoxine mesylate (DHET), an ergot alkaloid derivative, is widely used to treat senile cerebral vascular insufficiency. Aspects of this age‐related phenomenon may be due to deterioration by lipid oxidation of cellular membranes. DHET stabilizes EEG alpha frequencies, increases cerebral blood flow and oxygen uptake and accumulates in lipid‐rich structures of the brain. The effect of DHET was studied on iron‐catalyzed peroxidation of liposomes as measured by the thiobarbituric acid assay. It was found that DHET inhibits peroxidation in vitro in a dose‐dependent manner. These results suggest that DHET acts in part as a lipid antioxidant when used to treat senile cerebral vascular insufficiency.