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Hydroxylation of secondary bile acids in the perfused prairie dog liver
Author(s) -
Cohen Bertram I.,
Singhal Anil K.,
Mongelli Joseph,
Rothschild Marcus A.,
McSherry Charles K.,
Mosbach Erwin H.
Publication year - 1983
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534573
Subject(s) - deoxycholic acid , taurocholic acid , bile acid , chemistry , hydroxylation , chenodeoxycholic acid , biochemistry , medicine , enzyme
Taurolithocholic acid and deoxycholic acid were perfused into isolated prairie dog livers. Taurolithocholic acid was 7α‐hydroxylated to form taurochenodeoxycholic acid, whereas deoxycholic acid was conjugated and 7α‐hydroxylated to form taurocholic acid. The low concentrations of secondary bile acids observed in prairie dog bile are due, at least in part, to active bile acid 7α‐hydroxylase(s) in the liver of these animals.